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Member since: 2016
Organization: Novartis Pharma AG
LC-MALDI-MS as orthogonal technology to LC-ESI-MS
Application Area: Large scale proteomics experiments
"The TOF/TOF 5800 System was used in the lab in order to perform LC-MALDI-MS experiments. The system was found to be robust and relatively easy to use. Having a self-cleaning MALDI source helped to significantly decrease the number of interventions by service technicians. LC-MALDI-MS was found to deliver orthogonal information to LC-ESI-MS (e.g. different peptides identified, differences in the identification of phosphorlyation sites). Furthermore, the possibility of "storing" a chromatographic run on a MALDI target plate was extensively used, both for re-analysis of samples but also for new methods of relative protein quantification."
The SCIEX TOF/TOFTM 5800 System provides the fastest and most confident path to the identification and relative quantitation of proteins. The systems unmatched speed and sensitivity make it the ideal platform for biomarker discovery, MALDI mass spectrometry imaging, and protein identification.
Features of the TOF/TOFTM 5800 System: