Meet your quantitative needs with triple quadrupole performance which gives superior sensitivity, renowned performance reliability, and easy upgradeability. The Agilent 6400 Series Triple Quadrupole LC/MS Systems are the proven choice for your quantitative applications in pharmaceutical ADME/DMPK studies, biomarker validation, clinical research, food safety, forensics, toxicology, and environmental analyses.

Choose an Agilent 6420, 6430, 6460, or 6490 Triple Quadrupole LC/MS System for unmatched productivity, performance, and value for all your quantitative analysis needs. The 6420 is economical and easy to use – a perfect workhorse instrument for laboratories requiring standard quantitative capabilities. The 6430 offers improved sensitivity to yield more precise quantitation for most routine assays. The 6460 adds Agilent Jet Stream (AJS) technology to dramatically increase sensitivity for a wide range of challenging quantitative applications. The 6490 includes novel iFunnel technology for ultra-trace analysis – with attogram limits of quantitation and an unprecedented six orders of linearity for your most demanding quantitative analyses.

• Achieve the highest sensitivity – iFunnel technology dramatically increases ion sampling and transmission, enabling the lowest limits of detection and quantitation for your most demanding applications.
• Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation.
• Automate compound optimization – MassHunter Optimizer software automatically optimizes MRM transitions and fragmentor and collision energies for both small molecules and peptides.
• Higher scan speed – Full scan speeds of up to 12,500 Da/second allows you to take full advantage of today’s high throughput UHPLC chromatography.
• Ultra fast MRM acquisition speeds and ion polarity switching – An innovative collision cell eliminates cross-talk and enables 1ms MRM dwell times, together with 30 ms fast polarity switching, ensures compatibility with UHPLC analyses.
• Streamline method development – Dynamic MRM (dMRM) simplifies method development and allows up to 4,000 compounds to be quantified in a single method with optimal sensitivity and reproducibility.
• Compatibility with a wide range of ionization sources – ESI, AJS, APCI, APPI, Multi-mode sources, and innovative HPLC-Chip technology for robust and ultra-sensitive quantitation with small sample volumes.
• Comprehensive and easy-to-use MassHunter Workstation software dramatically enhances productivity from method optimization, data acquisition to data processing and reporting.