This mixed phase chemistry, in which two primary modes of attraction are present, allows for a more efficient and selective extraction compared to traditional reversed phase techniques. Neutral and ionized analytes can be simultaneously extracted from a complex mixture and eluted as separate fractions.
A mixed phase sorbent offers the following advantages:
Eluting acidic and neutral analytes separately from basic analytes
Selecting specific chemical interactions by nature of solvent and pH optimization to yield a more efficient extraction
Providing cleaner chromatograms by allowing contaminants either to pass through or be retained on the sorbent.
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