The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes.
Model Properties:
Coat Color: Black
Ideal For: Cardiac hypertrophy, heart failure
Strain Code: 510 HE, 511 HO, 512 WT, This model is cryopreserved.
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11BHSD2 Mouse Model
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The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes.
Model Properties:
- Coat Color: Black
- Ideal For: Cardiac hypertrophy, heart failure
- Strain Code: 510 HE, 511 HO, 512 WT, This model is cryopreserved.
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