EMD Millipore Introduces Novel Clarisolve® Depth Filters that Deliver Unmatched Speed and Efficiency for Single-Stage Clarification of Pretreated Feed Streams
17 Sep 2013

EMD Millipore, the Life Science division of Merck KGaA, Darmstadt, Germany, has introduced the Clarisolve® depth filter for single-stage clarification of pretreated feed streams. The Clarisolve® depth filter is a novel clarification device with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.

Delivering improved volumetric capacity and reduced turbidity over any currently available depth filtration technologies, Clarisolve® depth filters process pretreated feeds in a significantly reduced footprint without the need for the secondary stage of clarification. The use of Clarisolve® depth filters eliminates the need for centrifugation which enables implementation of a fully single-use process train, and also considerably reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high-product titer cell cultures.

”Until now, higher titers coming from upstream bioreactors have posed a challenge to conventional approaches to clarification,” described Vin Donovan, Vice President of Biopharm Process Solutions, EMD Millipore. “With Clarisolve® depth filters, our customers can now take full advantage of high density pretreated feed streams and improve overall process economics.”

EMD Millipore has also developed a cationic pDADMAC (poly diallyldimenthyl ammonium chloride) flocculation reagent targeted for biopharmaceutical applications which can be used as a pretreatment in combination with the Clarisolve® depth filters. pDADMAC treatment, in combination with Clarisolve® depth filters, provides an effective solution for harvesting high cell density cultures and can be easily incorporated into current clarification platforms.

Clarisolve® filters are available from lab, to pilot, to process scale in the industry leading disposable Pod format.

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EMD Millipore, a division of Merck KGaA, Darmstadt, Germany



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