Quest Diagnostics Launches Dementia Diagnostic Panel, First in Industry for Treatable Forms of Cognitive Impairment Based on Medical Guidelines
19 Mar 2013

Quest Diagnostics, the world's leading provider of diagnostic information services, today announced the availability of the first clinical test panel for aiding the diagnosis of suspected dementia due to treatable forms of cognitive impairment. The test panel is believed to be the first commercial service from a clinical laboratory to combine several guideline-recommended tests for identifying secondary, treatable causes of dementia as a single blood test and report.

Dementia is characterized by the presence of cognitive dysfunctions, such as memory loss and impaired judgment. The new test may help primary care physicians evaluate a patient presenting with cognitive impairment for potentially reversible causes of dementia, such as vitamin B12 deficiency, hypothyroidism, anemia and diabetes, based on results of biological lab tests. Patients with abnormal results may respond to treatment administered by a primary care physician to reverse the underlying cause of dementia. Patients with normal results may require evaluation by a neurologist for additional possible causes of dementia, including Alzheimer's disease.

The new panel of tests are modeled after the recommendations of the American Academy of Neurology, the American Geriatrics Association, a National Institutes of Health Consensus Panel and the European Federation of Neurological Societies.

"The evaluation of suspected dementia is a significant medical challenge because many different conditions, from low TSH levels to diabetes, can cause cognitive impairment," said Joseph J. Higgins, MD, FAAN, medical director for Quest Diagnostics Neurology and Athena Diagnostics. "Our new test panel provides a standard laboratory evaluation to rule out confounders of memory or reversible causes of memory loss. Test results are useful in excluding co-morbidities and revealing potential risk factors, origin of confusional states and, sometimes, in identifying the primary cause of dementia."

Athena Diagnostics is a leader in dementia diagnostics primarily for neurologists, with a menu that includes eleven testing services, including cerebrospinal fluid (CSF) biomarker analysis, to aid the detection of frontotemporal dementia and other forms of dementia, including Alzheimer's disease.
Quest Diagnostics acquired Athena Diagnostics in April 2011 in order to add neurology diagnostic information services to its business, although Athena continues to operate largely as an independent business and brand. Dementia experts at Athena Diagnostics helped to define the panel's tests and report requirements, while Quest Diagnostics' experts developed and introduced the comprehensive offering at clinical laboratories where the individual tests are performed.

"This test panel highlights the ability of Quest Diagnostics and Athena Diagnostics to introduce diagnostic innovations that conform with practice parameters and complete gaps in guideline-based medical care, which is central to our diagnostic information services strategy," said Jay G. Wohlgemuth, MD, senior vice president, science and innovation, Quest Diagnostics. "We expect it will be the first of additional diagnostic information services designed to improve neurology diagnosis to emerge from collaboration with Athena Diagnostics."

The test will be unveiled during the American Academy of Neurology Annual Meeting in San Diego, March 16-23, 2013 (Athena Diagnostics Booth 1413). At the conference, Athena Diagnostics will also introduce several new clinical lab-developed tests for a range of rare neurological disorders, including hereditary neuropathy and neuromuscular disease.

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