In this exclusive interview, Professor Victor Weedn, from The George Washington University, describes the current technologies in forensic science and their use in the criminal justice system. Currently, there is a demand for valid analysis of difficult samples such as complex mixtures, trace amounts and unknown unknowns that will stand up as evidence in a court of law, and it seems that mass spectrometry may be the technology to solve this problem.
The field of mass spectrometry is forever pushing the boundaries of small molecule analysis. Read on to discover the most recent advances in MS including analysis of unknowns, ultra-high resolution and software improvements to help deal with 'big data'.
With the World Cup in Brazil capturing the eyes of the world and the start of the Tour de France this week, SelectScience is looking at the slightly controversial performance-enhancing effects of caffeine.
Latest Mass Spectrometry Products
Visit the product directory to keep up-to-date with the latest advancements in Mass Spec technology and make informed purchasing decisions using information about the latest equipment.
How to Choose a Mass Spectrometer
Buying a new mass spectrometer is a huge investment, and with the variety and diversity of mass spectrometers on the market, it is important to make sure you purchase the instrument that best fits your needs and will bring a good return for your investment.
This buying guide provides you with information to help you make the right decision when choosing new mass spectrometry equipment. Learn about common mass spectrometer configurations, key applications areas, different factors to consider for purchase, as well as current and future trends in mass spectrometry. Throughout the Guide, you will find Buying Guide Tips, which are practical suggestions that might help in your pursuit for the most suitable mass spectrometer. The Guide ends with a Glossary of acronyms that are mentioned in the text and some common terms in mass spectrometry that could be useful, especially for those who are new to the technology.
Mass Spectrometry Applications and Methods
A Multidimensional Lipidomics Method: HILIC Coupled with Ion Mobility Enabled Time-of-Flight Mass Spectrometry
This application note presents a method combining HILIC-UPLC® liquid phase separation with gas phase ion mobility mass spectrometry for the multi-dimensional characterization of lipids in complex mixtures. The method enhances profiling of lipids in biological samples.
High Definition Data Directed Analysis: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Untargeted Proteomics Studies
The increasing complexity of bottom-up proteomics challenges the capabilities of mass spectrometers to generate more and more detailed information. Instrument speed, sensitivity, and mass accuracy have all increased significantly over recent years, and novel LC/MS acquisition schemas and fragmentation mechanisms have been introduced. In this study, instrumental and application benefits are demonstrated for the identification of proteins and peptides in a new high definition data directed analysis (HD-DDA) mode.
Metabolomics, a powerful tool in systems biology, aims to screen small metabolites present in biological samples. Given that water is the major constituent of cells, it is common to find a high number of hydrophilic metabolites. Traditional RP-LC/MS analysis of these compounds has been difficult due to poor retention and elution in the void volume. This study presents a HILIC-UPLC/MS strategy for the routine high-throughput screening of polar metabolites in biological samples.
This application note illustrates excellent chromatographic retention time reproducibility for a peptide standard injected on multiple iKeys during robustness testing of protein precipitated rat plasma, as well as the reproducibility between multiple ionKey/MS Systems operated by 5 independent scientists.
The application note uses the Compass PathwayScreener™ to enable mining the same full-scan high resolution LC-MS data set used for an initial non-targeted metabolomics workflow in a pathway-driven targeted fashion.
Thermo Fisher Scientific showcased 3 new Class I medical devices at AACC 2014. Watch this video to learn more about the HPLC, LC-MS and LC-MS software that have been designed to be components of laboratory-developed tests for analyzing patient samples.
Prof. Nicholson describes personalized medicine and how delivering the correct treatment for the right individual, based on their genes and environment, could be the future of healthcare. The use of mass spectrometry and NMR spectroscopy enables an overview of hundreds of thousands of metabolites in a single analytical run covering a large number of physiological and metabolic processes. This gives an insight as to how one might respond to treatment. Personalized medicine has the opportunity to save lives, shorten journeys, and save money.
Dr Matthew Lewis describes how the MRC-NIHR Phenome Centre investigates what makes people metabolically different. By analyzing large cohorts of patients and performing epidemiological studies, an insight into the understanding of human metabolism can be achieved. NMR and UPLC mass spectrometry are used with a combination of different chromatography methods to gain accurate analysis of small molecules in human samples.
Watch this video to learn how mass spectrometry is used for metabolomics research. Elizabeth Want, PhD., Imperial College, explains her research involving the development and optimization of mass spectroscopy based metabolite profiling. Solutions provided by Waters have allowed for higher throughput, increased sensitivity, and less time required.
Professor Christopher Elliott describes how developments in mass spectrometry enable reliable detection of food fraud, as a result of advances in targeted and untargeted methodologies.
A New Concept in Metabolic Studies: How Personalized 'Sportomics' Bridges Bench and Clinical Science
In this webinar, Prof. L. C. Cameron will describe a novel, sportomics approach to studying exercise-induced changes in the human metabolome. Discover new solutions to analyzing small data sets, and discover how the sportomics approach can bridge the gap between bench top and clinical science, furthering our understanding of hypermetabolic disease states.
Latest Technology News
Waters® Corporation has announced that the Chinese Food and Drug Administration (CFDA) approved the registration of the ACQUITY UPLC® TQD system for legal promotion and sale in China as a medical device for routine diagnostic applications and neonatal metabolites diseases screening.
AB SCIEX, a global leader in analytical technologies, has confirmed its commitment to support the diagnostic market with the unveiling of the Triple Quad™ 4500MD and QTRAP® 4500MD LC/MS/MS systems under its SCIEX Diagnostics brand. The systems were showcased at the AACC 2014 Annual Meeting and Clinical Lab Expo last week.
Waters Corporation recently announced the acquisition of Rapid Evaporative Ionization Mass Spectrometry (REIMS) technology from MediMass Ltd. The REIMS technology represents substantially all of the assets of MediMass and includes patent applications, software, databases and REIMS expertise.
Clinical laboratories around the world are focused on reporting quality and truth in results, and LC-MS is becoming the analytical technique of choice. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing.
AB SCIEX, a global leader in life science analytical technologies, today introduced the StatusScope™ Remote Monitoring service, a configurable, real-time offering that supports most AB SCIEX mass spectrometers and Eksigent Micro and Nano LC products.