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Mass Spectrometry

Mass spectrometry (MS) is an analytical technique used across several different scientific disciplines to identify unknown compounds within a sample and determine the chemical structure of a substance.

What's New

Advances in Forensic Science: Could Mass Spec Have its Day in Court?

In this exclusive interview, Professor Victor Weedn, from The George Washington University, describes the current technologies in forensic science and their use in the criminal justice system. Currently, there is a demand for valid analysis of difficult samples such as complex mixtures, trace amounts and unknown unknowns that will stand up as evidence in a court of law, and it seems that mass spectrometry may be the technology to solve this problem.

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7 Recent Advances in Mass Spectrometry – And How They Could Revolutionize Your Research

The field of mass spectrometry is forever pushing the boundaries of small molecule analysis. Read on to discover the most recent advances in MS including analysis of unknowns, ultra-high resolution and software improvements to help deal with 'big data'.

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Caffeine Effects on Sporting Performance – Part 2: Pros and Cons

With the World Cup in Brazil capturing the eyes of the world and the start of the Tour de France this week, SelectScience is looking at the slightly controversial performance-enhancing effects of caffeine.

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Latest Mass Spectrometry Products

Visit the product directory to keep up-to-date with the latest advancements in Mass Spec technology and make informed purchasing decisions using information about the latest equipment.

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How to Choose a Mass Spectrometer

Mass Spectrometer image

Buying a new mass spectrometer is a huge investment, and with the variety and diversity of mass spectrometers on the market, it is important to make sure you purchase the instrument that best fits your needs and will bring a good return for your investment.

This buying guide provides you with information to help you make the right decision when choosing new mass spectrometry equipment. Learn about common mass spectrometer configurations, key applications areas, different factors to consider for purchase, as well as current and future trends in mass spectrometry. Throughout the Guide, you will find Buying Guide Tips, which are practical suggestions that might help in your pursuit for the most suitable mass spectrometer. The Guide ends with a Glossary of acronyms that are mentioned in the text and some common terms in mass spectrometry that could be useful, especially for those who are new to the technology.


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Mass Spectrometry Applications and Methods

A Multidimensional Lipidomics Method: HILIC Coupled with Ion Mobility Enabled Time-of-Flight Mass Spectrometry

A Multidimensional Lipidomics Method: HILIC Coupled with Ion Mobility Enabled Time-of-Flight Mass Spectrometry

This application note presents a method combining HILIC-UPLC® liquid phase separation with gas phase ion mobility mass spectrometry for the multi-dimensional characterization of lipids in complex mixtures. The method enhances profiling of lipids in biological samples.

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High Definition Data Directed Analysis: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Untargeted Proteomics Studies

High Definition Data Directed Analysis: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Untargeted Proteomics Studies

The increasing complexity of bottom-up proteomics challenges the capabilities of mass spectrometers to generate more and more detailed information. Instrument speed, sensitivity, and mass accuracy have all increased significantly over recent years, and novel LC/MS acquisition schemas and fragmentation mechanisms have been introduced. In this study, instrumental and application benefits are demonstrated for the identification of proteins and peptides in a new high definition data directed analysis (HD-DDA) mode.

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Development of a Metabolomic Assay for the Analysis of Polar Metabolites Using HILIC UPLC/QTof MS

Development of a Metabolomic Assay for the Analysis of Polar Metabolites Using HILIC UPLC/QTof MS

Metabolomics, a powerful tool in systems biology, aims to screen small metabolites present in biological samples. Given that water is the major constituent of cells, it is common to find a high number of hydrophilic metabolites. Traditional RP-LC/MS analysis of these compounds has been difficult due to poor retention and elution in the void volume. This study presents a HILIC-UPLC/MS strategy for the routine high-throughput screening of polar metabolites in biological samples.

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Chromatographic Reproducibility of the Novel ionKey/MS System

Chromatographic Reproducibility of the Novel ionKey/MS System

This application note illustrates excellent chromatographic retention time reproducibility for a peptide standard injected on multiple iKeys during robustness testing of protein precipitated rat plasma, as well as the reproducibility between multiple ionKey/MS Systems operated by 5 independent scientists.

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Compass PathwayScreener™ – Metabolic-Pathway–Directed Targeted Metabolomics

The application note uses the Compass PathwayScreener™ to enable mining the same full-scan high resolution LC-MS data set used for an initial non-targeted metabolomics workflow in a pathway-driven targeted fashion.

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Videos

Brand New LC-MS Based Medical Devices Debut at AACC 2014

Brand New LC-MS Based Medical Devices Debut at AACC 2014

Thermo Fisher Scientific showcased 3 new Class I medical devices at AACC 2014. Watch this video to learn more about the HPLC, LC-MS and LC-MS software that have been designed to be components of laboratory-developed tests for analyzing patient samples.

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Personalized Medicine: The Future of Healthcare

Personalized Medicine: The Future of Healthcare

Prof. Nicholson describes personalized medicine and how delivering the correct treatment for the right individual, based on their genes and environment, could be the future of healthcare. The use of mass spectrometry and NMR spectroscopy enables an overview of hundreds of thousands of metabolites in a single analytical run covering a large number of physiological and metabolic processes. This gives an insight as to how one might respond to treatment. Personalized medicine has the opportunity to save lives, shorten journeys, and save money.

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Metabonomics: Understanding Human Metabolism

Metabonomics: Understanding Human Metabolism

Dr Matthew Lewis describes how the MRC-NIHR Phenome Centre investigates what makes people metabolically different. By analyzing large cohorts of patients and performing epidemiological studies, an insight into the understanding of human metabolism can be achieved. NMR and UPLC mass spectrometry are used with a combination of different chromatography methods to gain accurate analysis of small molecules in human samples.

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Mass Spectrometry based Metabolomics Profiling

Mass Spectrometry based Metabolomics Profiling

Watch this video to learn how mass spectrometry is used for metabolomics research. Elizabeth Want, PhD., Imperial College, explains her research involving the development and optimization of mass spectroscopy based metabolite profiling. Solutions provided by Waters have allowed for higher throughput, increased sensitivity, and less time required.

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The Future of Mass Spectrometry in Food Science

The Future of Mass Spectrometry in Food Science

Professor Christopher Elliott describes how developments in mass spectrometry enable reliable detection of food fraud, as a result of advances in targeted and untargeted methodologies.

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Webinars

A New Concept in Metabolic Studies: How Personalized 'Sportomics' Bridges Bench and Clinical Science

A New Concept in Metabolic Studies: How Personalized 'Sportomics' Bridges Bench and Clinical Science

In this webinar, Prof. L. C. Cameron will describe a novel, sportomics approach to studying exercise-induced changes in the human metabolome. Discover new solutions to analyzing small data sets, and discover how the sportomics approach can bridge the gap between bench top and clinical science, furthering our understanding of hypermetabolic disease states.

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Latest Technology News

Waters ACQUITY UPLC TQD System Receives Medical Device Approval in China

Waters ACQUITY UPLC TQD System Receives Medical Device Approval in China

Waters® Corporation has announced that the Chinese Food and Drug Administration (CFDA) approved the registration of the ACQUITY UPLC® TQD system for legal promotion and sale in China as a medical device for routine diagnostic applications and neonatal metabolites diseases screening.

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AB SCIEX Announces the 4500MD Series for In Vitro Diagnostic Use

AB SCIEX Announces the 4500MD Series for In Vitro Diagnostic Use

AB SCIEX, a global leader in analytical technologies, has confirmed its commitment to support the diagnostic market with the unveiling of the Triple Quad™ 4500MD and QTRAP® 4500MD LC/MS/MS systems under its SCIEX Diagnostics brand. The systems were showcased at the AACC 2014 Annual Meeting and Clinical Lab Expo last week.

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Waters Acquires REIMS Technology, Strengthens Health Science Initiative

Waters Acquires REIMS Technology, Strengthens Health Science Initiative

Waters Corporation recently announced the acquisition of Rapid Evaporative Ionization Mass Spectrometry (REIMS) technology from MediMass Ltd. The REIMS technology represents substantially all of the assets of MediMass and includes patent applications, software, databases and REIMS expertise.

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LC-MS is the Technique of Choice for Clinical Labs

LC-MS is the Technique of Choice for Clinical Labs

Clinical laboratories around the world are focused on reporting quality and truth in results, and LC-MS is becoming the analytical technique of choice. Accurate test results are necessary for clinical research and discovery, as well as routine diagnostic testing.

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AB SCIEX StatusScope™ Remote Monitoring Service Enables Troubleshooting and Control via Smartphone

AB SCIEX StatusScope™ Remote Monitoring Service Enables Troubleshooting and Control via Smartphone

AB SCIEX, a global leader in life science analytical technologies, today introduced the StatusScope™ Remote Monitoring service, a configurable, real-time offering that supports most AB SCIEX mass spectrometers and Eksigent Micro and Nano LC products.

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Expert Reviews in Mass Spec

QTRAP® 6500 LC/MS/MS System

QTRAP® 6500 LC/MS/MS System

This instrument has excellent sensitivity and good selectivity...
Bianca, JRFAmerica

QTRAP® 6500 LC/MS/MS System stars

SYNAPT G2-Si HDMS

SYNAPT G2-Si HDMS

Provides high resolution and accurate Mass for both intact mass and peptide mapping analysis...Yingqing Sun, Pfizer, Inc

SYNAPT G2-Si HDMS SYNAPT G2-Si HDMS 4 stars

Thermo Scientific Exactive™ Plus EMR Orbitrap™ LC-MS

Thermo Scientific Exactive™ Plus EMR Orbitrap™ LC-MS

Amazingly sensitive and fast mass spec with incredibly high mass range and spectral resolution...
Stefano Gotta, Novartis Vaccines and Diagnostics

Thermo Scientific Exactive™ Plus EMR Orbitrap™ LC-MS stars

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