Industry News: Novel Antibodies Developed Against a Groundbreaking New Target for the Treatment of Cardiovascular Fibrosis

Enleofen Bio and Abzena are working together to develop first-in-class antibody therapeutics for the treatment of fibrotic human diseases

15 Nov 2017


The Founders of Enleofen Bio discovered that inhibiting Interleukin 11 (IL11) prevents fibrosis through a wide range of pathways, putting it at the very centre of the fibrotic process. This breakthrough research was recently published in Nature. Enleofen Bio has also developed a wide range of potent IL11 inhibitors and its fully human antibody development program is now being advanced with the use of Abzena’s Composite CHO™ cell line technology. Enleofen Bio may in the future opt to progress with large scale manufacturing at Abzena’s San Diego facility.

Abzena will also support Enleofen Bio through the development of alternative strategies to block IL11 signalling. Abzena’s wide range of protein engineering technologies will help to translate findings from successful proof-of-concept studies in preclinical models of disease to the clinic. Enleofen is currently investing proceeds from a successful Series A fundraising into the development of novel fibrosis treatments. Enleofen has an exclusive licence to a comprehensive suite of patent applications covering IL11’s role in fibrosis and a range of products to treat fibrosis.

Prof Stuart Cook, co-founder of Enleofen Bio, commented:

“IL11 is a truly outstanding drug target for preventing fibrosis. Organ fibrosis causes deaths of millions of people around the world and current treatment options are very limited. We believe anti-IL11 therapies will transform the treatment of patients suffering from fibrosis of the lung, heart, liver, kidneys and other organs.

“We chose to work with Abzena because of its proven expertise in antibody engineering and cell line development.” 

Campbell Bunce, SVP Scientific Operations, said:

“We believe our expertise and integrated offering across biology and biomanufacturing will allow Enleofen Bio seamless development across its portfolio of novel treatments for preventing fibrosis.

“This agreement represents another example of customers using a range of Abzena’s services to enable their biopharmaceutical development program.”

Read the research article published in Nature here