Industry News: ACEA Biosciences and Ncardia Global Partnership to Provide Solutions for Cardiac Drug Discovery and Cardiac Safety Assessment

Pioneer of real-time cell analysis instrumentation will join forces with leading provider of iPSC-derived cardiomyocytes

01 Dec 2017


ACEA Biosciences (ACEA), a pioneer and leader in label-free real-time cell analysis instrumentation, and Ncardia, a leading expert in human cardiovascular stem cell technology, disease modelling and cell-based assay products and services, announced today that they have established a global partnership to provide comprehensive solutions for cardiac drug discovery and cardiac safety assessment.

This multifaceted partnership will include the joint development of applications, co-marketing, and commercial activities. Central to this partnership will be the coupling of ACEA’s innovative xCELLigence® Real-Time Cell Analysis (RTCA) Cardio and CardioECR instruments with Ncardia’s fully functional Pluricyte® and Cor.4U® human iPSC-derived cardiomyocytes, providing a complete assay system for pure and applied cardiomyocyte research.

Ncardia, is an emerging drug discovery and development stem cell technology company whose goal is to be the trusted global leader in the hiPSC drug discovery and development field and the partner of choice for scientists operating in cardiovascular and neural safety and efficacy projects. Using its cell products, Ncardia develops and commercializes electrophysiology-, biochemistry-, and contraction-based assay services for predictive safety pharmacology, toxicology testing, and drug efficacy screening. In addition, the company has built up a strong portfolio of patents covering the use of stem cell models for these applications. Ncardia believes that stem cell technology fast-tracks the delivery of better medicines to patients by improving the drug discovery process.

ACEA is the developer of seven different xCELLigence RTCA instruments, more than 2,000 of which have been installed in academic, industry, and government laboratories globally. The xCELLigence RTCA CardioECR model is the only instrument in the world that combines high frequency (every 1 millisecond) measurement of cell-induced electrical impedance with multielectrode array technology to simultaneously assess cardiomyocyte contractility, viability, and electrophysiology in a microtiter plate format. Moreover, the CardioECR’s electrical pacing feature enables the functional maturation of cardiomyocytes, improving the efficacy and predictivity of inotropic compound screening.

ACEA and Ncardia will officially launch their partnership with a limited-time promotion that includes the xCELLigence CardioECR instrument packaged with Ncardia Pluricyte or Cor.4U Cardiomyocytes at a discounted price.  Yama Abassi, VP of Global Business Development at ACEA, stated “we are happy to establish this relationship with Ncardia to provide innovative solutions to the global market. Moving forward, some of our offerings will include pre-plated cells so that existing customers can use their time more efficiently.” Stefan Braam, CEO of Ncardia mentioned that “working with ACEA, and particularly the xCELLigence CardioECR instrument, will ensure that our customers will obtain optimum value from our Pluricyte and Cor.4U Cardiomyocytes and be able to maximally capitalize on Ncardia’s predictive and translational in vitro solutions for drug safety and efficacy testing”.

Starting in early 2018 ACEA and Ncardia will offer joint demonstrations and workshops focused on optimizing cardiomyocyte research by coupling the CardioECR instrument with Pluricyte and Cor.4U cells.  Jointly hosted user meetings, aimed at promoting scientific exchange and collaboration amongst scientists working at the forefront of cardiac safety assessment and cardiovascular disease modelling, are also slated for the new year.