High Content Screening

Read user reviews, compare products and contact manufacturers of High Content Screening products, including imaging analysis, software and assays on SelectScience.

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PHERAstar FS®  

5 out of 5



High-throughput-screening (HTS) microplate reader The PHERAstar ® FS from BMG LABTECH rivals CCD-based devices The perfect solution for screening and assay development. With all...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

20 review(s) of this product / Read All

acumen® Cellista Laser Scanning Imaging Cytometer  

4 out of 5



acumen® Cellista – the fastest high content screening system. acumen Cellista is a microplate-based laser scanning imaging cytometer designed to provide rapid, whole well, content-rich...
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  • Ease of use 4 out of 5
  • After sales service 5 out of 5
  • Value for money 4 out of 5

7 review(s) of this product / Read All

DRAQ5  

5 out of 5



DRAQ5™ is a novel far-red fluorescent LIVE cell DNA dye that can be used in combination with other common fluors, especially GFP fusions & FITC-tags. DRAQ5™ has many applications and...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

35 review(s) of this product / Read All

upcyte® Hepatocytes  

upcyte® Hepatocytes are genetically engineered human cell strains, derived from single donor primary cells. The assay-ready standardized cells exhibit primary features. Applications...
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NovoCyte  

NovoCyte is a Game-Changer in the field of Flow Cytometry. It allows you to concentrate on you experiments rather than on the instrument's manual. Newly developed for a seamless...
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DRAQ7  

5 out of 5



DRAQ7 fluoresces in the far-red – with the same spectral properties that have made DRAQ5™ a reagent of choice in HCS. DRAQ7™ only labels membrane-compromised dead, dying and apoptotic...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

5 review(s) of this product / Read All

CyFlow® Space – Ultra-Compact, High-End, Multi-L...  

This family of ultra-compact, high-end, multi-laser, benchtop flow cytometry systems is highly versatile and can be equipped for most applications in cell and particle analysis and...
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Dainippon SCREEN Cell3iMager  

A rapid, robust imager for monitoring spheroid growth and morphology. The Dainippon SCREEN Cell3iMager provides estimated values regarding the number, size, optical density and volume...
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CYP2D6 competent upcyte® Hepatocytes  

CYP2D6 recombinantly expressed in upcyte® Hepatocytes donor 653-03. upcyte® Hepatocytes are genetically engineered human cell strains, derived from single donor primary cells. The...
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CyGEL  

5 out of 5



A thermoreversible gel compatible with LIVE cells. It can be used to immobilise non-adherent cells and beads by simple warming, and conversely allowing their recovery by simple cooling.
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

upcyte® Liver Sinusoidal Endothelial Cells (LSEC...  

upcyte® LSECs are genetically engineered human cell strains, derived from single donor primary cells. The assay-ready standardized cells exhibit primary features. Applications...
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ImageXpress® Ultra Confocal High Content Screeni...  

4 out of 5



ImageXpress® Ultra System offers the ultimate solution when crisp, clear images are a priority. Under control of state-of-the-art MetaXpress® Software, research-quality images of...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

4 review(s) of this product / Read All

POLARstar® Omega  

4 out of 5



The POLARstar Omega is a multi-mode microplate reader that can perform all microplate based assays, including fluorescence polarization (FP) experiments. Having Simultaneous Dual...
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  • Ease of use 5 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

12 review(s) of this product / Read All

CyGEL Sustain  

5 out of 5



CyGEL Sustain is a novel thermoreversible gel that is compatible with extended imaging of LIVE cells, for several hours depending on cell type. Its special formulation is optimised for...
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  • Ease of use 4 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

MetaXpress® High Content Image Acquisition & Ana...  

MetaXpress® Software is the premier image acquisition and analysis software for high-content screening (HCS), built upon the industry-leading MetaMorph® Software with over 25 years of...
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upcyte® Bronchial Epithelial Cells (BEpCs)  

upcyte® BEpCs are genetically engineered human cell strains, derived from single donor primary cells. The assay-ready standardized cells exhibit primary features. Applications...
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HypoxiTRAK  

HypoxiTRAK™ is a novel, far-red fluorescing dye that reveals the hypoxic experience of individual cells. It is non-toxic to normoxic cells. HypoxiTRAK™ enables entirely new...
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SynStats Statistical Module  

SynStats is a new generation statistical module designed to make the analysis of results simple and easy to use and interpret. The SynStats module fits seamlessly alongside the...
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MARS Data Analysis Software  

Well organized, versatile, easy to use and powerful are just a few of the ways to describe BMGLABTECH’S microplate reader MARS Data Analysis Software package. Based upon the powerful...
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Definiens Architect XD™  

3 out of 5



Definiens Architect XD™ enables non-technical users to configure, calibrate, and execute image analysis workflows with great versatility. Users can configure new workflows using a...
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  • Ease of use 2 out of 5
  • After sales service 4 out of 5
  • Value for money 3 out of 5

1 review(s) of this product / Read All

Definiens Developer XD™  

Definiens Developer XD™ - The most powerful development environment for automated image analysis. Definiens Developer XD enables the development of image analysis solutions for...
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Definiens Image Miner®  

Definiens Image Miner® integrates data mining with image analysis to accelarate research and development in life sciences. Image Miner enables review and quality control of image...
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Definiens Server XD™  

Definiens Server XD™ is a processing component that allows the batch processing of image analysis jobs. It is hugely scalable and capable of handling millions of images in a single...
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Definiens Tissue Studio® 3  

5 out of 5



Definiens Tissue Studio 3 is the solution of choice for biomarker and morphological profiling in translational research. It is easy to use, robust, powerful, and fast. It accurately...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

BioFlux 200  

BioFlux provides a fully integrated solution for running biologically relevant cellular assays under shear flow. The system utilizes Fluxion's Well Plate Microfluidics™ (WPM) to provide...
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BlueScreen HC - S9  

BlueScreen HC uses a single cell strain, which permits 8 compounds to be tested across 8 dilutions (2-fold serial), together with untreated and positive controls, in one 96-well microplate.
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BlueScreen HC: The luminescent adaptation of Gre...  

BlueScreen HC is based on the fast, accurate GreenScreen HC genotoxicity assay from Gentronix Ltd. BlueScreen HC uses the same human-derived, p53-competent TK6 cells to host a...
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GreenScreen HC  

Gentronix has launched a new, accurate and fast in vitro mammalian cell genotoxicity assay - GreenScreen HC. The TK6 host cells are p53 competent and familiar to most genetic...
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GreenScreen HC - S9 (Human Cells) and Metabolic ...  

In 2008 Gentronix launches a new S9 protocol to extend the application of the GreenScreen HC assay to include the detection of genotoxic metabolites. Many pharmaceuticals only present...
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ActivityBase Suite  

4 out of 5



IDBS ActivityBase  - Capture, store, secure, analyze and share discovery data The IDBS ActivityBase suite provides efficient and effective drug discovery data management, enabling...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 3 out of 5

2 review(s) of this product / Read All

ChemBook (E-WorkBook for chemistry)  

Providing a complete research management environment that allows chemists to manage the entire lifecycle of their research, ChemBook (E-WorkBook for chemistry) extends the...
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MultiPep RS  

The MultiPep RS is an automated multiple peptide synthesizer based on a pipetting robot operated by a dedicated PC software. Synthesis is being performed in 96 well filter plates, in...
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Exciton Laser Dye  

Exciton specialize in the development and manufacture of the highest quality fluorescent and absorber dyes and dye stabilisers for applications ranging from fluorescent tags, OLEDs, neon...
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MACSQuant® VYB Analyzer  

4 out of 5



With unparalleled features, the MACSQuant VYB is set to excite the world of flow cytometry. The MACSQuant VYB is a compact benchtop flow cytometer featuring 3 lasers and detection of 10...
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  • Ease of use 4 out of 5
  • After sales service 3 out of 5
  • Value for money 4 out of 5

3 review(s) of this product / Read All

ImageXpress® Micro Widefield High Content Screen...  

4 out of 5



The ImageXpress® Micro System together with state-of-the-art MetaXpress® Software provides a fully-automated solution to capture research-quality, widefield images of fixed- or live-cell...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

6 review(s) of this product / Read All

ImageXpress® Micro XL Widefield High Content Scr...  

4 out of 5



The ImageXpress® Micro XL System increases your field of view by three times the area, giving you statistically relevant results in a third of the time. Its new, interactive tools let you...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

4 review(s) of this product / Read All

Thermo Scientific ArrayScan Infinity High Conten...  

For drug discovery, systems biology and general cell biology the ArrayScan* Infinity High Content Platform brings the latest advances in multi-dimensional high-content imaging and...
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Vi-CELL® XR Cell Viability Analyzer  

4 out of 5



The Vi-CELL Series Cell Viability Analyzers provide an automatic and cost effective means to perform the trypan blue dye exclusion method. This data is essential to the decision making...
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  • Ease of use 5 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

16 review(s) of this product / Read All

Agilent RNA 6000 Nano Reagents  

The Agilent RNA kits with the patented RNA Integrity Number (RIN) are the industry standard for RNA quality assessment. Do fast, easy and precise integrity checks and sample quantitation...
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Agilent RNA 6000 Pico Reagents  

The Agilent RNA kits with the patented RNA Integrity Number (RIN) are the industry standard for RNA quality assessment. Do fast, easy and precise integrity checks and sample quantitation...
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Agilent Small RNA Reagents  

The Agilent RNA kits with the patented RNA Integrity Number (RIN) are the industry standard for RNA quality assessment. Do fast, easy and precise integrity checks and sample quantitation...
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Passive Reference Dye  

Brilliant probe-based QPCR reagents provide maximum versatility in real-time PCR detection. These master mixes and core reagent kits are compatible with any fluorescent probe chemistry,...
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Universal microRNA Reference Kit   

The Stratagene Universal Human miRNA Reference RNA is an ideal reference control for miRNA microarray or miRNA-targeted QRTPCR experiments. The Universal Human miRNA Reference RNA may also...
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Coulter Epics XL™ and XL-MCL™ Flow Cytometer  

4 out of 5



This unique system redefines the standards of flow-cytometric analysis. The flow cytometer combines the analytical power of a research cytometer into a compact, truly walk away, clinical...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

9 review(s) of this product / Read All

EasyCyte Plus System  

Guava's cell and bead-based assays are designed to make the most critical cellular assays accessible to life science researchers everywhere. Guava assays minimize training time and...
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Guava easyCyte 5HT Flow Cytometer  

Guava EasyCyte Mini   Once again Guava is making flow cytometry accessible to anyone in the lab. Novice and experts alike will appreciate the latest addition to Guava’s on-demand...
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Image Stream®X Mark II Imaging Flow Cytometer  

4 out of 5



The revolutionary ImageStream®X Mark II Imaging Flow Cytometer combines the speed, sensitivity, and phenotyping abilities of flow cytometry with the detailed imagery and functional insights...
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  • Ease of use 4 out of 5
  • After sales service 5 out of 5
  • Value for money 4 out of 5

1 review(s) of this product / Read All

Multiparameter Cellular Analysis easyCyte™ Bench...  

4 out of 5



New easyCyte benchtop flow cytometers are user-friendly and powerful, facilitating complex multiparameter cell analyses. The single and dual laser formats with higher performance detect a...
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  • Ease of use 5 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

1 review(s) of this product / Read All

PCA Personal Cell Analysis System  

Guava Technologies is revolutionizing single cell analysis with its compact cytometry systems, most notably in the Guava PCA system. The Guava PCA system is one of the most compact...
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PCA-96 System  

The Guava PCA-96 systems provide automated, higher throughput screening of 96-well microplates or a tray of microcentrifuge tubes. This flexible sample format makes the Guava PCA-96 systems...
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Opera Phenix High Content Screening System  

The Opera Phenix™ High Content Screening System is the premier confocal solution for today's most demanding high content applications With the Opera Phenix High Content Screening...
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Operetta® High Content Imaging System  

4 out of 5



Operetta High Content Screeng System - High Content Imaging and Analysis That Simply Works. The Operetta® High Content Imaging System from PerkinElmer is the ideal solution for...
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  • Ease of use 4 out of 5
  • After sales service 5 out of 5
  • Value for money 4 out of 5

2 review(s) of this product / Read All

CyTRAK Orange  

A fluorescent dye staining both nucleus and cytoplasm. It is water soluble and membrane permeant and can be used in LIVE cells in combination with other common fluors, especially GFP...
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CyFlow® CCA - Cell Counter Analyser  

Dedicated Flow Cytometer for DNA Cell Cycle Analysis and Cell Counting For all applications in cell counting: Eukaryotic cell cultures (mammalian cell cultures | plant cell...
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RapidFire Epigenetic Assay Development & Screeni...  

Assays for methylases, acetylases, phosphorylases and other modifying enzymes involved in histone and chromatin modulation are developed and optimized by RapidFire scientists for primary...
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FLARE™ Assay  

The FLARE Assay (Fragment Length Analysis using Repair Enzymes) provides the ability to detect DNA damage in single cells using a variety of DNA repair enzymes in conjunction with Comet...
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XTT Cell Proliferation Assay Kit  

5 out of 5



XTT Cell Proliferation Assay Kit procedure avoids radioactivity, allows for rapid determination in microplates, and gives reproducible and sensitive results. Measurement of cell...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

BD FACSAria Cell-Sorting System  

4 out of 5



The BD FACSAria™ III is built on the solid foundation of patented technologies, superior multicolor performance, and legendary ease-of-use that has led to the unparalleled success of the...
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  • Ease of use 3 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

7 review(s) of this product / Read All

BD FACSArray™ Bioanalyzer System  

3 out of 5



BD FACSArray™ Bioanalyzer System - One instrument. Beads and cells. Infinite discovery. Access the Possibilities - BD FACSArray™ Bioanalyzer System The BD FACSArray™ bioanalyzer is...
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  • Ease of use 4 out of 5
  • After sales service 3 out of 5
  • Value for money 3 out of 5

1 review(s) of this product / Read All

BD FACSCalibur Flow Cytometer  

4 out of 5



BD FACSCalibur - The flow cytometer for your routine cell analysis needs The BD FACSCalibur Flow Cytometry System is another BD first: the only four-color, dual-laser, benchtop...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

23 review(s) of this product / Read All

BD FACSCanto™ Flow Cytometer  

4 out of 5



When performance matters BD has been innovating flow cytometry since the release of the first commercial flow cytometer in 1974. That tradition continues with the new BD FACSCanto™...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

11 review(s) of this product / Read All

BD LSR II System  

4 out of 5



Four-laser, 18-color benchtop flow cytometer Building on the ease of use and flexibility of the BDTM LSR, the first UV benchtop analyzer, BD Biosciences introduces the BDTM LSR II. The...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

13 review(s) of this product / Read All

BD LSRFortessa™ Cell Analyzer  

4 out of 5



The special order BD LSRFortessa™ cell analyzer puts the power of the proven BD LSR platform into a compact footprint. Approximately half the size of the BD™ LSR II, it can easily fit...
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  • Ease of use 4 out of 5
  • After sales service 4 out of 5
  • Value for money 4 out of 5

1 review(s) of this product / Read All

AD6000 Gantry Platform  

The AD6000 Gantry Platform is a workstation designed for high throughput biochip manufacturing. Vision inspection (CCD camera) and barcode reading can be configured for verification of...
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OpenArray® Pathways Apoptosis Panel Kit.  

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels...
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OpenArray® Pathways Human Transcription Factors ...  

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels...
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OpenArray® Pathways Inflammation Disease Panel K...  

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels...
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OpenArray® Pathways Mouse Inflammation Panel Kit  

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels...
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OpenArray® Pathways Mouse Transcription Factors ...  

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels...
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OpenArray® Pathways Signal Transduction Disease ...  

Real-Time qPCR assays for Signal Transduction and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real-Time qPCR Case, Immersion Fluid, Frame Adhesive and...
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KINACore  

Ligand-based selection method using pharmacophores of low energy adenosine conformers; applicable to all kinase targets, including tyrosine and serine/threonine kinases.
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MicroFormats™  

A ready to screen collection of 100,000 to 200,000 small molecules, pre-plated in DMSO in 0.25 umol and higher amounts and 0.1mg to 5mg amounts. Over 60 proprietary chemical filters and...
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SciFinder - Online Scientific Literature Search  

5 out of 5



CAS SciFinder -  The First Choice With SciFinder from CAS, you can increase your productivity and achieve faster breakthroughs Advancing the pace of research, Chemical...
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  • Ease of use 5 out of 5
  • After sales service 4 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

STN - Online Scientific Database Literature and ...  

STN is an online database service that provides global access to published research, journal literature, patents, structures, sequences, properties, and other data. 
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DropArray™ Accelerator HT200  

The DropArray™ Accelerator HT200 allows higher level of automation for researchers. It provides similar benefits to DropArray™ Accelerator LT100 with additional features required for our...
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DropArray™ Accelerator LT  

The DropArray™ Accelerator LT is the first in a series of products offered by Curiox. The Accelerator LT targets users in research labs performing ELISA and cell adherent assays. The...
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Definiens Viewer XD™  

Definiens Viewer XD™ enables users to review the results of any image analysis produced within Definiens XD. The application's intuitive interface lets users load, view and export...
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KINOMEscan™ Binding Assays  

The KINOMEscan screening platform employs a novel and proprietary active site-directed competition binding assay to quantitatively measure interactions between test compounds and more...
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Brefeldin A Solution 1 mL  

Brefeldin A is an inhibitor of intracellular protein transport. Incubation of cells in culture with Brefeldin A leads to blockade of protein transport to the Golgi complex (GC) and...
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Cell Proliferation Dye eFluor® 670 4 x 500 ug  

Cell Proliferation Dye eFluor® 670 is a red fluorescent dye that can be used to monitor individual cell divisions. This fluorescent dye binds to any cellular protein containing primary...
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CellVue Diluent C (For CellVue® Cell Labeling Ki...  

Diluent C is the Buffer required for the dilution of the dyes in the CellVue® Cell Labeling Kits. Please refer to the specific labeling kit for instructions of use.
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CFSE 5 x 500 ug  

CFSE is widely used for cell tracking and proliferation studies. It has also been used in CTL assays and cell motility studies. CFSE readily crosses intact cell membranes. Once inside the...
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Monensin Solution 1 mL  

Monensin is an inhibitor of intracellular protein transport. Incubation of cells in culture with Monensin leads to blockade of protein transport to the Golgi complex (GC) and accumulation...
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OncoPanel™ 240  

OncoPanel 240 enables large scale cellular testing through a diverse panel of well-defined tumor cell lines with published gene expression profile and clinical biomarker data. Panlabs...
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IN Cell Analyzer 2200 Imaging System  

IN Cell Analyzer 2200 Imaging System IN Cell Analyzer 2200 is a super-fast and sensitive wide-field cell imaging system, fine-tuned to the needs of the entire high-content analysis (HCA)...
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Genedata Screener  

5 out of 5



Scaling to any amount of data, Genedata Screener® captures, analyzes and manages all types of screening data on a single platform. Its superior performance and screening-specific business...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

NanoCell  

4 out of 5



NanoCell - A Compact Modular Robotic System NanoCell offers all the flexibility and modularity of the High Res MicroStar, but does so over a very small footprint. Coupling an...
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  • Ease of use 4 out of 5
  • After sales service 5 out of 5
  • Value for money 4 out of 5

1 review(s) of this product / Read All

ActivityBase XE  

IDBS ActivityBase XE - Superior template design flexibility offers a revolutionary solution for enhancing high throughput screening data management ActivityBase XE delivers ultra high...
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ATPase or GTPase Assay Kits  

Feel the need for speed in your lead development time? The Answer – High Through Put Screening ATPase or GTPase Assays from Innova Biosciences. Is your drug discovery program for...
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MultiPep CF  

The MultiPep CF is a fully automated peptide synthesizer with a unique column module that allows the synthesis of long and difficult sequences. During the synthesis, reagents are...
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iQue® Screener  

5 out of 5



Expanding capabilities, increasing performance, getting results! IntelliCyt continues to expand the capabilities and performance of the iQue ® Screener, an automated platform for high...
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  • Ease of use 5 out of 5
  • After sales service 5 out of 5
  • Value for money 5 out of 5

1 review(s) of this product / Read All

MultiCyt 4-Plex Apoptosis Screening Kit  

The MultiCyt Apoptosis Screening Kit is a mix and read screening assay using a unique combination of reagents that allow simultaneous screening of five different apoptosis endpoints per...
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IRDye® 800CW 2-DG Optical Probe  

Cancer cells are often characterized by a high metabolic rate exemplified by an elevated rate of glycolysis. This observation forms the basis for positron emission tomography (PET) using...
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IRDye® 800CW EGF Optical Probe  

IRDye® 800CW EGF Optical Probe are near-infrared (NIR) labeled recombinant human epidermal growth factor (EGF). Epidermal growth factor receptor (EGFR) is one of a family of receptor...
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IRDye® 800CW PEG Contrast Agent  

IRDye 800CW PEG Contrast Agent (25-60 kDa) is a non-specific imaging agent intended to exploit EPR in tumor biology. Enhanced permeability and retention (EPR) is a common characteristic...
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IRDye® 800CW RGD Optical Probe  

IRDye 800CW RGD Optical Probe is a near-infrared labeled BrightSite™ imaging agent specifically designed to target the overexpression of integrins on tumors. Integrins are cell surface...
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PSVue® 794 Reagent Kit  

PSVue® 794 is a near-infrared fluorescent probe for detection of apoptotic and necrotic cells, bacteria and other anionic membranes. The compound exhibits fluorescence excitation maximum...
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RediPlate™ 96 EnzChek® Serine/Threonine Phosphat...  

The RediPlate™ 96 EnzChek® Serine/Threonine Phosphatase Assay Kit provides a fast, simple and direct fluorescence-based assay for detecting serine/threonine phosphatases and their...
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upcyte® Hepatocyte Starter Kit  

upcyte® Hepatocytes are genetically engineered human cell strains, derived from single donor primary cells. The assay-ready standardized cells exhibit primary features. Applications...
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upcyte® Skeletal Muscle Cells (SkMCs)  

Skeletal muscle cells are responsible for all voluntary body movements which are established by contractions of the skeletal muscles. An impaired skeletal muscle function is ...
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