Electrophysiology

The ACCN31 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC3 channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel ... Read more...

Human Cav2.2/β3/α2δ1 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4159. Three vials of Cyropreserved irradiated cells, 2x10E6 cells/vial (6x10E6 cells total). Platform validation: PatchXpress® Read more...

The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely di... Read more...

The HCN4 gene encodes the pore-forming subunit of a hyperpolarization-gated, cyclic nucleotide-sensitive, non-selective cation channel. HCN4 channels expressed in the heart contribute to the pacemaker current (Ih) and are therapeutic targ... Read more...

The human KCNA3 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Kv1.3 channels expressed in lymphocytes are therapeutic targets in autoimmune diseases. Synonyms: hKv1.3 Host cell: CHO-K1, division-arre... Read more...

The human KCNQ1 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Co-expression with minK, an auxiliary subunit, recapitulates native function in heterologous expression (CHO cells). KvLQT1/minK channels expresse... Read more...

The human KCNQ4 gene encodes the pore-forming subunit of a voltage-gated potassium channel. KCNQ4 channels expressed in CNS neurons are therapeutic targets in epilepsy. Synonyms: Kv7.4 Host cell: CHO-K1, division-arrested Gene ... Read more...

The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and ... Read more...

The human SCN1A gene encodes the pore-forming subunit of voltage-gated type-1 Na+ channels. Neuronal Nav1.1 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-1 sodium channel Host cell: CHO-K1 ... Read more...

Th e human Nav1.2 gene encodes the pore-forming subunit of voltage-gated type-2 Na+ channels. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-2 sodium channel Host cell: CHO-K1 ... Read more...

The SCN3A gene encodes the pore-forming subunit of the voltage-gated type-3 Na+ channel. Neuronal Nav1.3 channels are therapeutic targets in seizure and pain. Synonyms: brain type-3 sodium channel Host cell: CHO-K1, division-arre... Read more...

The SCN4A gene encodes the pore-forming subunit of the voltage-gated, skeletal muscle Na+ channel. Nav1.4 is a therapeutic target for treatment of myotonia. Synonyms: Skeletal muscle sodium channel, SkM1 Host cell: CHO-K1, divisi... Read more...

The human Nav1.5 gene encodes the pore-forming subunit of the voltage-gated, cardiac Na+ channel. Nav1.5 is an antiarrhythmic therapeutic target. Synonyms: cardiac sodium channel Host cell: CHO-K1 Gene name: SCN5A Mycoplasma... Read more...

The SCN8A gene encodes the pore-forming subunit of a voltage-gated Na+ channel. Neuronal Nav1.6 channels are therapeutic targets in pain treatment. Synonyms: NaCh6, PN4 Host cell: CHO-K1, division-arrested Gene name: SCN8A M... Read more...

The human Nav1.7 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in sensory and sympathetic neurons. The Nav1.7 channel is a therapeutic target in pain treatment. Synonyms: PN1 Host cell: C... Read more...

Human α4/β2 Nicotinic Acetylcholine Receptor-expressing, transiently transfected cells (HEK293). Cat#: CT7023. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: QPatch™ HT Read more...

Evaluate compounds in human stem cell-derived, ventricular-type cardiomyocytes. Effects on action potential parameters are evaluated in single human cardiomyocytes using patch-clamp recording Benefits: Human ion channels expresse... Read more...

Human Cav2.2/β3/α2δ calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6159. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , FLIPR® Read more...

Human Nav1.8/b3 sodium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6011. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , IonWorks Quattro® Read more...

Human a3/β4 Nicotinic Acetylcholine Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6021. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: QPatch HT™ Read more...

Human GABAA (α5β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6119. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR® Read more...

Human GABAA (a5β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6119. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR® Read more...

Human Cav2.2/b3/a2d calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6159. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , FLIPR® Read more...

Human Cav2.1/b4/a2d calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6196. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ Read more...

Human GABAA (α3/β2/γ2) Receptor-expressing, transiently transfected cells (HEK293). Cat#: CT7022. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: PatchXpress®, FLIPR® Read more...