Drug Discovery Laboratory Application Articles and Drug Discovery Scientific Posters on SelectScience

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Analysis of Tricyclic Antidepressants in Human Urine Using UltraPerformance Convergence Chromatography (UPC²)
24 May 2013

Tricyclic antidepressants (TCAs) are an older class of drug traditionally analyzed using GC, UV, or LC/MS. This application note describes the successful implementation of UltraPerformance Convergence Chromatography™ for the analysis of and quantification of four TCAs in human urine. Results demonstrate the utility and benefits of this novel separation technology in the important application area of bioanalysis.

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Detection of Opioids and Opiates in Dried Blood Spots Using the Agilent Automated Card Extraction LC/MS System	drugs of abuse, forensic toxicology, Opiates	3 May 2013	Read
Cell-Based Screening of Focused Bioactive Compound Libraries: Assessing Small Molecule Modulators of the Canonical Wnt Signaling and Autophagy-Lysosome Pathways	aggregation, library generation, neurobiology	2 May 2013	Read
Targeted Metabolomics Analysis of Cell Culture Lysates using the AbsoluteIDQ™ p180 Kit	metabolites, metabolomics, lymphocytes	2 May 2013	Read
Targeted Metabolomics Analysis of Cerebrospinal Fluid Using the AbsoluteIDQ™ Kit	neuroscience, metabolites, metabolomics	2 May 2013	Read
Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo® Liquid Handler	CYP, cytochrome p450 assays, CYP3A4	2 May 2013	Read
Cardiovascular: Platelet – Thrombosis – Adhesion Assay	thrombosis, microfluidics, cardiology	1 May 2013	Read
Oncology: Melanoma – Metastasis	cancer, melanoma, oncology	1 May 2013	Read
Applying Transfection Technologies to Create Novel Screening Models	cytotoxicity, human cardiomyocytes, iPSC	30 Apr 2013	Read
Metabolomic Analysis using the AbsoluteIDQ™ p150 Kit in combination with the AB Sciex 5500 QTrap® Mass Spectrometer	metabolites, drug development, metabolomics	30 Apr 2013	Read
Analysis of Human Urine Using the AbsoluteIDQ™ Kit	metabolites, urine analysis, metabolomics	30 Apr 2013	Read