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Analysis of Tricyclic Antidepressants in Human Urine Using UltraPerformance Convergence Chromatography (UPC²)
24 May 2013

Tricyclic antidepressants (TCAs) are an older class of drug traditionally analyzed using GC, UV, or LC/MS. This application note describes the successful implementation of UltraPerformance Convergence Chromatography™ for the analysis of and quantification of four TCAs in human urine. Results demonstrate the utility and benefits of this novel separation technology in the important application area of bioanalysis.

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Total Organic Carbon (TOC) Analyzers in Pharmaceutical Applications	ultrapure water, water analysis, TOC monitoring	23 May 2013	Read
Analysis of USP <467> Residual Solvents using the Agilent 7697A Headspace Sample with the Agilent 7890B Gas Chromatograph	solvent monitoring, chromatography method development, headspace sampler	23 May 2013	Read
Improving Laboratory Efficiency & Flexibility with Automated Sample Preparation Systems: The Impact of the Gilson GX‐281 Dual Z‐Arm Weighing Station	laboratory management, liquid handling workstation, barcode scanner	23 May 2013	Read
Streamlining and Non-Compliant Intact Mass Analysis of Biotherapeutic mAbs with the Biopharmaceutical Platform Solution	monoclonal antibodies, therapeutic antibodies	23 May 2013	Read
Analysis of Persistent Organic Pollutants in Complex Matrices by GC-HR TOFMS	pesticides, environmental contamination, persistent organic pollutants	21 May 2013	Read
Routine Assessment of Cancer Cell Cytotoxicity in a Novel Three Dimensional Culture Assay	3d cell culture, cytotoxicity, breast cancer	21 May 2013	Read
Using the CASY Cell Counter and Analyzer for Proliferation and Viability Measurement in Oncological Studies	apoptosis, cell viability, cell analysis	21 May 2013	Read
Separation of Recombinant Human Erythropoietin (rhEPO) using the European Pharmacopoeia Method on the PA 800 plus Pharmaceutical Analysis System	pharmaceuticals, Erythropoietin	21 May 2013	Read
HaloPlex Target Enrichment from FFPE Tissues	DNA extraction, target-enrichment, FFPE extraction	20 May 2013	Read
Next-Generation Amplicon-Based Deep Sequencing and Its Application to Characterize Hematological Malignancies	leukemia, NGS, KRAS	17 May 2013	Read