Application Note: Two Dimensional HPLC using a High pH Stable Superficially Porous Column
20 June 2014

The analysis of impurities is an important part of the development process in chemical industries. Due to the fact that impurities can be structurally similar to the main compound it can often be difficult to separate them chromatographically. A solution to this challenge can be the use of the Agilent 1290 Infinity 2D-LC. This work presents a column packed with superficially porous particles that are stable in a wider pH range.