Application Note: Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP™ System
24 January 2008

In this application note, several different metabolite identification approaches are evaluated for their merits.

Common strategies require two mass spectrometry systems: a triple quadrupole system for metabolite identification and an ion trap system for metabolite characterization.

With the advent of the hybrid triple quadrupole-linear ion trap (LIT) instrumentation available in the 4000 Q TRAP™ System, both triple quadrupole and ion trap scans can now be performed on the same instrument in a single experiment.

This simplifies the apparatus and improves metabolite identification.