Application Note: RapidFire® In Vitro ADME Applications
8 April 2010

This application note demonstrates the correlation between traditional LC-MS and RapidFire for a spectrum of ADME assays. The RapidFire® MS System is shown to perform in vitro ADME assays rapidly and without modifications to existing assay methods. Sample cycle times of approximately 6 seconds can also be achieved obtaining a 7 point IC50 curve in 42 seconds.