Application Note: Rapid Characterization of Variable Regions of Monoclonal Antibodies by Top-Down Sequencing using Synapt HDMS
30 November 2007

The Waters Synapt HDMS System combines high-efficiency ion mobility with high-performance tandem mass spectrometry. This application note demonstrates the use of the Synapt HDMS system to quickly obtain a partial amino acid sequence of a monoclonal antibody (MAb) via a top-down approach.