Application Note: Predictive Assays for High Throughput Assessment of Cardiac Toxicity and Drug Safety
3 February 2012
In this poster a method is demonstrated for measuring the impact of pharmacological compounds on beating stem-cell derived human cardiomyocytes using the ImageXpress® Micro and the FLIPR® Tetra systems from Molecular Devices, LLC. Both methods allow monitoring of drug impact on the beat rate and amplitude in 96 or 384 well formats. The method demonstrated use of both systems for two important applications: screening compounds for cardiac toxicity, and pre-clinical testing of potential cardiac drug candidates.