Application Note: Determination of Impurities and Related Substances for Acetylsalicylic Acid (Ph. Eur. Monograph 0309): Increased Sensitivity and Resolution, Faster Analysis, and Reduced Solvent Usage Using Kinetex™ 2.6 μm Core-Shell LC Columns
21 May 2012

This note demonstrates the performance benefits of the new core-shell technology (similar to fully porous sub-2 μm particles but at substantially lower operating pressures). A Kinetex 2.6 μm core-shell C18 column was compared with a fully-porous 5 μm C18 column referenced in European Pharmacopoeia [Ph. Eur.] Monograph 0309 for Acetylsalicylic acid and related substances on a conventional HPLC instrument with an upper pressure limit of 400 bar.