Application Note: High-Throughput Analysis of Epigenetic Targets with Agilent RapidFire/MS Systems: p300 Histone Acetyltransferase (HAT)
24 October 2013

This application note describes how the Agilent RapidFire platform enables high-throughput mass spectrometric analysis of native molecules from in vitro reactions by performing online desalting in seconds. Epigenetic changes which involve sequential modifications are an ideal application for the Agilent RapidFire System because it can directly detect multiple states of peptides and proteins discretely.