Application Note: Fully automated sitting drop protein crystallization with CyBi®-CrystalCreator using JBScreen Basic HTS Kit
27 April 2007

Knowledge of the three-dimensional structure of biological macromolecules can reveal essential information about their function, offering a unique opportunity to facilitate drug discovery. The most common experimental method of gaining a detailed picture of a protein, allowing the resolution of individual atoms, is single-crystal X-ray crystallography. Growing high-quality protein crystals is still a major bottleneck and very time consuming step in this process. This application note describes screening experiments using the fully automated CyBi®-CrystalCreator in combination with a commercially available crystallization screen from Jena Bioscience.



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