Application Note: Charge and Interaction Analysis for Predicting Antibody Formulation Stability
23 January 2016

This application note demonstrates how combined measurements of net charge and kD can help us to understand the difference between two formulations with different stability behavior. In this example, although the formulations have the same net charge, secondary effects of asymmetric charge distributions and hydrophobic residues result in the stability differences. This article illustrates how the Wyatt Möbius’ capabilities can be used to gain a more thorough understanding of factors affecting a protein’s stability.

Download PDF >>PDF Icon

Read the full article...

  Become a member
  • Quick and complete access to all application articles

  • Download 10,000+
    applications and methods

  • Make informed buying decisions


Already a member?

Log in for full access to the article




Remember me