Application Note: Automated Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cell-Mediated Cytotoxicity Utility
7 October 2013
The selection of potent and selective monoclonal antibodies for specific target receptors is the first step in successfully developing an antibody-based drug. In addition to potent binding, some antibodies have the ability to activate Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC). The ability to promote ADCC is an important attribute of successful candidates, and should be sought in the final drug design. This application note demonstrates that the combination of assay and instrumentation create a powerful, easy to use and efficient method to screen and characterize antibodies being considered for use in ADCC applications.