Application Note: Quantitation of Trace Level Emerging Contaminants in Water Using Online SPE with LC/MS/MS
16 October 2013

This application note demonstrates the performance of an Agilent Infinity Series Online SPE Solution in combination with an Agilent 6460 Triple Quadrupole LC/MS System for the analysis of chemicals on US EPA’s Contaminant Candidate List 3 at trace levels in water. This method shows excellent performance for detecting 12 challenging contaminants, with a limit of quantitation (LOQ) < 0.1 for all target compounds. Analysis of samples from real sources including ground water, lake, and flood control reservoir showed good results for tebucanzole.