Application Note: Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS
5 December 2013

Screening of β-amyloid secretase (BACE-1) against a fragment library using two substrates, a labeled and an unlabeled peptide, which were detected either by FS or ultrafast SPE/MS/MS using the Agilent RapidFire High-throughput MS System.

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