Application Note: High-Throughput MS Detection of Histone H3 Demethylation by Lysine-Specific Demethylase 1 (LSD1)
7 January 2012

In this application note, the results obtained using the RapidFire/MS system to analyze the
serial demethylation of histone H3 by LSD1 are illustrated. Because RapidFire/MS can measure
multiple analytes from each sample quickly and directly, the system is particularly applicable for studying epigenetic changes which involve sequential modifications, and is designed to provide unparalleled data for lead discovery.