Application Note: A Generic UHPLC/UV/MS Method for Cleaning Verification of Highly Potent Drugs
3 Jun 2014

This application shows a generic Cleaning Verification (CV) method using Liquid Chromatography, which is a Good Manufacturing Practices (GMP) requirement in manufacturing of drug substances and drug products. The study shows a 2-minute generic CV method in a concentration range of 0.5 ng/mL to 1,000 ng/mL for five model drug compounds and shows the identification of unknown compounds employing a user-supplemented NIST Mass Spectral Search Program.