Application Note: Relative Viscosity Screening of Monoclonal Antibody (mAb) Formulations at Low Concentration and Low Viscosity for Early Stage Developability

24 June 2015

This application note details measurements of a mAb in various formulation buffers, and with the addition of common excipients, to show the small variations in viscosity with concentration and excipient changes that the microcapillary flow technique is able to reliably measure. The ability to screen early stage candidates and formulations for abnormal viscosity changes, using measurements at low concentrations and very low sample volumes, can help identify monoclonal antibodies (mAbs) with potential developability issues.

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