Application Note: Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies
12 December 2012

To comply with U.S. FDA guidelines regarding the safety of drug metabolites in human plasma, there is a need to rapidly evaluate and accurately quantify multiple, diverse drug candidates and metabolites in a discovery or preclinical setting. Methodologies that are generic, fast, and robust are featured in this application note from Waters using Ostro 96-well plates and XBridge BEH XP 2.5 µm columns for accurate metabolite ratio determination.

Download PDF >>PDF Icon

Read the full article...

  Become a member
  • Quick and complete access to all application articles

  • Download 10,000+
    applications and methods

  • Make informed buying decisions


Already a member?

Log in for full access to the article




Remember me

Company