Application Note: Pathway-Targeted Metabolomic Analysis in Oral/Head and Neck Cancer Cells Using Ion Chromatography-Mass Spectrometry
16 February 2015
Separation science plays an important role in metabolomics by reducing the sample complexity to achieve a comprehensive profiling analysis. Recently, an analytically sensitive platform coupling capillary ion chromatography with a Thermo Scientific™ Q Exactive™ mass spectrometer has been successfully developed for nontargeted metabolic profiling of head and neck cancer cells. This application note demonstrates ion chromatography coupling with high-resolution, accurate-mass (HRAM) MS for targeted metabolomics analysis.