Application Note: Importance of TOC measurement in WFI in light of European Pharmacopoeia change
15 November 2017

The new revision of the European Pharmacopoeia chapter on Water for Injection (WFI) now permits the generation of WFI using Reverse Osmosis1 (RO), paving the way for  companies to reduce their energy bills and carbon footprint by moving away from using stills. This paper discusses the increased focus on Total Organic Carbon (TOC) and conductivity measurement, especially for companies seeking to use RO water treatment plants to create WFI, and provides best-practice advice for calibration.