Identifying and Collecting Weak UV Absorbance and Low Level Peaks of Interest from a Complex Mixture Using Conditional Logic Purification on Mass and UV Signals>

Application Articles

Identifying and Collecting Weak UV Absorbance and Low Level Peaks of Interest from a Complex Mixture Using Conditional Logic Purification on Mass and UV Signals
24 May 2012

This application note demonstrates the improvement in specificity offered by LC/MS based purification when compared to traditional UV alone using the Gilson GX‐271 LC/MS Purification System. API purification was simulated using a mixture of several pharmaceuticals at varying concentration levels.