High Performance Peptide Mapping Using Varian Capillary LC Columns>

Application Articles

High Performance Peptide Mapping Using Varian Capillary LC Columns
30 Jul 2008

Proteomics studies have played more and more important roles in drug development and biomarker discovery. Proteins in a sample (body fluids, serum/plasma, or tissue extract) are separated and identified by liquid chromatography-mass spectrometry (LC-MS). For protein-based biomarkers, the use of multidimensional LC coupled with MS and MS-MS is becoming a standard technology.

This application note describes the how Varian capillary LC columns can be used for LC-MS separation of a tryptic digest of Bovine Serum Albumin (BSA).