Application Note: Conformer Isolation in Intrinsically Disordered Protein Ensembles Using DMS-MS

24 June 2014

This poster describes the isolation of various native/ phosphorylated tau conformers and isobaric tau phosphopeptides using DMS with chemical modifier gases. Native tau displayed two broad mobility peaks regardless of types of modifier gases used. This can be rationalized by dipole locking theory.

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