Application Note: Acceleration of Antibody Development Campaigns from Cell Line Generation through Functional Characterization
8 March 2018
Generating antibodies specific to membrane-spanning proteins in their native conformation is very challenging, yet crucial for therapeutic and diagnostic antibody development. The advantage of traditional cell-based assays is that they facilitate the study of antibody-antigen interactions in their native environment, however, they are limited by low sample throughput and require large sample volumes. This poster highlights how using the IntelliCyt® iQue Screener platform enabled ModiQuest Research to develop increasingly complex, multi-criteria assays thus reducing sample volume requirements, time to results and FTE requirements while maximizing chances of finding therapeutic leads in less time.
