Application Note: A Universal LB-MSIA Workflow using Freedom EVO Platform for the Quantitative Analysis of Intact Therapeutic Antibodies of Different Allotype Subclasses
1 April 2016
This application note demonstrates the effectiveness of quantitatively analyzing therapeutic mAbs of different constructs and allotype subclasses from rodent plasma using the Thermo Scientific™ enhanced capacity MSIA™ Streptavidin EVO microcolumns. This pre-clinical bioanalytical solution, on the Tecan Freedom EVO® platform, is based on mass spectrometric detection, specific for the bioanalysis of humanized, fully human and chimeric therapeutic monoclonal antibodies.