Application Note: A Simple, Robust Automated Multiplex Assay for Mitochondria Toxicity Testing
5 November 2012

Drug compound mitotoxicity, or toxicity within mitochondria, is now an important part of testing during drug discovery. Multiplexed cell-based mitochondrial assays increase sample throughput and decrease variability, costs and overall time for project completion. The utility of an automated multiplex assay to both assess and distinguish between cytotoxicity and mitochondrial function is presented in this application note from BioTek. The assay was carried out in both primary hepatocytes and immortalized HepG2 liver carcinoma cells.  The combination of instrumentation, assay chemistry and primary hepatocytes is an ideal solution to accurately predict potential mitochondrial toxicity in lead compounds.

Download PDF >>PDF Icon

Read the full article...

  Become a member
  • Quick and complete access to all application articles

  • Download 10,000+
    applications and methods

  • Make informed buying decisions

Already a member?

Log in for full access to the article

Remember me