CD11c (αX integrin subunit) forms complex with CD18 (β2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other β2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
|Reactivity||Human, Non-Human Primate|
|Storage||Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.|
|Buffer||The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.|
|Flow Cytometry (FC), Immunohistochemistry (Formalin-Fixed Sections) (IHC (F)), Immunohistochemistry (Frozen Sections) (IHC (Fr)), Immunoprecipitation (IP)|