CyFlow™ CD11a Low Endotoxin

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Product Details

Manufacturer
Cat. No.
CH435905
Type
Primary Antibody
Clonality
Monoclonal
Host
Rat

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Description

CD11a (LFA-1 α) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αβ2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.

Alternative Names

LFA-1

Biological Information

Clonality Monoclonal
Host Rat
Reactivity Mouse
Antigen CD11a
Conjugate Low Endotoxin
Isotype IgG2a

Handling

Quantity 0.1 mg
Format liquid
Storage Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Buffer The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Applications

Flow Cytometry (FC), Functional Studies (Func), Immunohistochemistry (Formalin-Fixed Sections) (IHC (F)), Immunoprecipitation (IP)

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CyFlow™ CD11a Low Endotoxin


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Manufacturer:
Catalogue Number:
CH435905
Antibody Type
Primary Antibody