The CD8b (CD8 β) subunit of CD8 T cell coreceptor is expressed in CD8 α/β heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 α/α homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 α/β but not α/α dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Clonality | Monoclonal |
Host | Mouse |
Reactivity | Rat |
Antigen | CD8b |
Conjugate | PE |
Isotype | IgG1 |
Handling | |
Quantity | 0.1 mg |
Format | liquid |
Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
Buffer | The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide. |
Applications | |
Flow Cytometry (FC), Functional Studies (Func), Immunohistochemistry (Formalin-Fixed Sections) (IHC (F)), Immunoprecipitation (IP), Western Blotting (WB) |