CyFlow™ CD8a Purified

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Product Details

Manufacturer
Cat. No.
CC027137
Type
Primary Antibody
Clonality
Monoclonal
Host
Rat

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Description

The CD8a (CD8 α) subunit of CD8 T cell coreceptor is expressed in CD8 α/β heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 α/α homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 α/β but not α/α dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Alternative Names

T8, Leu2

Biological Information

Clonality Monoclonal
Host Rat
Reactivity Mouse
Antigen CD8a
Conjugate Purified
Isotype IgG2a

Handling

Quantity 0.1 mg
Format liquid
Storage Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Buffer The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

Flow Cytometry (FC), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)

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CyFlow™ CD8a Purified


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Manufacturer:
Catalogue Number:
CC027137
Antibody Type
Primary Antibody