CyFlow™ CD5 FITC

Be the first to review this product

Product Details

Manufacturer
Cat. No.
CJ255719
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse

Buy Now

Place your order directly with the manufacturer.

Description

CD5 (T1) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.

Alternative Names

Leu-1

Biological Information

Clonality Monoclonal
Host Mouse
Reactivity Human
Antigen CD5
Conjugate FITC
Isotype IgG2a

Handling

Quantity 100 tests
Format liquid
Storage Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

Flow Cytometry (FC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blotting (WB)

0 Scientists have reviewed this product


Write the First Review

No Reviews

Antibody Overview

Product Image

CyFlow™ CD5 FITC


Be the first to review this product

Manufacturer:
Catalogue Number:
CJ255719
Antibody Type
Primary Antibody