CyFlow™ CD3 Low Endotoxin

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Product Details

Manufacturer
Cat. No.
AD466530
Type
Primary Antibody
Clonality
Monoclonal
Host
Hamster

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Description

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3 δ, CD3ε and CD3ζ. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.

Alternative Names

T3, Leu4

Biological Information

Clonality Monoclonal
Host Hamster
Reactivity Mouse
Antigen CD3
Conjugate Low Endotoxin
Isotype IgG

Handling

Quantity 0.1 mg
Format liquid
Storage Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Buffer The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Applications

Flow Cytometry (FC), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (Formalin-Fixed Sections) (IHC (F)), Immunoprecipitation (IP)

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CyFlow™ CD3 Low Endotoxin


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Manufacturer:
Catalogue Number:
AD466530
Antibody Type
Primary Antibody