CyFlow™ CD3 Biotin

Be the first to review this product

Product Details

Manufacturer
Cat. No.
BG087977
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse

Buy Now

Place your order directly with the manufacturer.

Description

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 γ, CD3 δ, CD3 ε and CD3 ζ. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

Alternative Names

T3, Leu4

Biological Information

Clonality Monoclonal
Host Mouse
Reactivity Human
Antigen CD3
Conjugate Biotin
Isotype IgG2a

Handling

Quantity 0.1 mg
Format liquid
Storage Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Buffer The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

Flow Cytometry (FC), Functional Studies (Func), Immunoprecipitation (IP)

0 Scientists have reviewed this product


Write the First Review

No Reviews

Antibody Overview

Product Image

CyFlow™ CD3 Biotin


Be the first to review this product

Manufacturer:
Catalogue Number:
BG087977
Antibody Type
Primary Antibody