Tecan’s newly launched AC Extraction Plate is a revolutionary, automation-friendly solution designed to streamline sample preparation for LC-MS analysis of small molecules. The plate, which is based on proprietary TICE™ (Tecan Immobilized Coating Extraction) technology, reduces the sample preparation process to a convenient ‘pipette and shake’ routine. The AC Extraction Plate is a 96-position, deep-well microplate, with the inner surface of each well coated with a highly controlled layer of TICE material. This coating efficiently extracts low molecular weight analytes – such as vitamin D and testosterone – from aqueous solutions, eliminating the need for the laborious and time-consuming filtration, centrifugation and evaporation steps that are often integral to other methods. Unlike many of these techniques, sample preparation with the AC Extraction Plate can also be easily automated, providing a rapid, walkaway solution for the extraction of small molecules from biological fluids for LC-MS analysis.